Dean

Yung-Luen Yu

Professor Yung-Luen Yu

  • Name: Yung-Luen Yu
  • E-mail:  ylyu@mail.cmu.edu.tw
  • Office Address: 9F, No.6, Hsueh-Shih Road, Graduate Institute of Biomedical Sciences, China Medical University,  Taichung 404, Taiwan
  • Phone:   886-4-22052121 EXT.7933

Education

  • Ph.D., Graduate Institute of Life Sciences, National Defense Medical Center (1996-2002)
  • M.S., Graduate Institute of Life Sciences, National Tsing Hua University (1993-1995)
  • B.S., Department of Horticulture, Chinese Culture University (1988-1992)

Current Positions

  • Dean, Graduate Student Affairs, China Medical University
  • Professor, Graduate Institute of Biomedical Sciences, China Medical University
  • Research Fellow, Center for Molecular Medicine, China Medical University Hospital

Porfessional/Academic Experence

  • Dean: Graduate Student Affairs, China Medical University (2017.02-)
  • Professor: Graduate Institute of Biomedical Sciences, China Medical University (2016.08-)
  • Director: Graduate Institute of Cancer Biology, China Medical University (2011.02-2016.07)
  • Professor: Graduate Institute of Cancer Biology, China Medical University (2015.08-2016.07)
  • Research Fellow: Center for Molecular Medicine, China Medical University Hospital (2011.04-)
  • Associate Professor: Graduate Institute of Cancer Biology, China Medical University (2011.02-2015.07)
  • Assistant Professor: Graduate Institute of Cancer Biology, China Medical University (2007.01-2011.01)
  • Postdoctoral fellow: Department of Molecular and Cellular Oncology , University Texas M. D. Anderson Cancer Center (2005-2007)
  • Postdoctoral fellow: Institute of Biomedical Sciences, Academia Sinica (2002-2004)

Specialties

  • Cancer Epigenetic and Signaling

Awards and Honors

  • Distinguished Teaching Professor, College of Medicine, China Medical University (2009)
  • Distinguished Teaching Professor, College of Medicine, China Medical University (2007)

Society Memberships

  • American Association for Cancer Research (2010-present)
  • Phi Tau Phi Scholastic Honor Society (1993-present)

Grant

  • 2016/08~2018/07 CMU Grant (桂冠研究人才計畫)
    (CMU105-AWARD-02) (105/08-107/07)
  • 2015/08~2017/07 Ministry of Science and Technology (MOST) Grant
    The role of EZH2 in homing of mesenchymal stem cells into the ischemic brains and its clinical implications
    (MOST104-2321-B-039-005) (104/08-106/07)
  • 2014/08~2017/07 Ministry of Science and Technology (MOST) Grant
    The Roles of Globo H Expression in Hepatocellular Carcinoma Progression
    (NSC103 2320-B-039-052-MY3) (103/08-106/07)
  • 2014/01~2017/12 Ministry of Health and Welfare (MOHW)
    The second CRC of Excellence of MOHW
    (MOHW104-TDU-B-212-124-002) (103/01-106/12)
  • 2013/01~2015/12 National Health Research Institutes (NHRI)
    Roles of Human Polynucleotide Phosphorylase in DNA Damage Response and Tumor Progression
    (NHRI-EX102-10245BI) (102/01-104/12)
  • 2011~ 2012 Sister Institution Network Fund (SINF)
    (joint grant between MDACC and CMHU)
    Nuclear EGFR in Cancer Cell Signaling and Radioresistance
  • 2011/10~2014/09 National Science Council (NSC) Grant
    Epigenetic Regulation of Neuron Differentiation in hMSCs and its Clinical Implications in Neurological Dysfunction Diseases
    (NSC100 2321-B-039-004) (100/10-103/09)
  • 2010/12~2011/09 National Science Council (NSC) Grant
    Molecular Mechanisms of Neuron Differentiation in Human Mesenchymal Stem Cells
    (NSC99 3111-B-039-002) (99/12-100/09)
  • 2010/08~2013/07 National Science Council (NSC) Grant
    Roles of Tyrosine Phosphorylated PCNA in Tumor Progression
    (NSC99 2320-B-039-030-MY3) (99/08-102/07)
  • 2010/08~2013/07 National Science Council (NSC) Grant
    Cell Signaling Pathway in Cancer Progression
    (NSC99 2632-B-039-001-MY3) (99/08-102/07)
  • 2007/12~2010/11 National Science Council (NSC) Grant
    Molecular Mechanisms of Neuron Differentiation in Human Mesenchymal Stem Cells
    (NSC96 3111-B-039-003) (96/12-99/11)
  • 2007/08~2010/07 National Science Council (NSC) Grant
    The Nuclear Function of EGF Receptor in Cancer Cell Proliferation
    (NSC96 2320-B-039-032-MY3)(96/08-99/07)

Selected publications (*Correspondence; Co-first author)

  • Chen W…, Yu YL…, Lee SF, Chiang YJ, Chao JR, Huang JH, Chiong JH, Huang CJ, Lai MZ, Yang-Yen HF, and Yen JJY*. CREB is one component of the binding complex of the Ces-2/E2A-HLF binding element and is an integral part of the interleukin-3 survival signal. Mol Cell Biol.2001 21: 4636-46.
  • Yu YL, Chiang YJ, and Yen JJY. GATA *factors are essential for transcription of the survival gene E4bp4 and the viability response of interleukin-3 in Ba/F3 hematopoietic cells. J Biol Chem.2002 277: 27144-53.
  • Yu YL, Chiang YJ, Chen YC, Papetti M, Juo CG, Skoultchi AI, and Yen JJY*. MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. J Biol Chem. 2005 280: 29533-42.
  • Wang SC…, Nakajima Y…, Yu YL…, Xia W, Chen CT, Yang CC, McIntush EW, Li LY, Hawke DH, Kobayashi R, and Hung MC*. Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Bio. 2006 8(12): 1359-1368.
  • Yiang GT…, Yu YL…, Hu SC, Chen MHC, Wang JJ, and Wei CW*. PKC and MEK pathways inhibit caspase-9/-3-mediated cytotoxicity in differentiated cells. FEBS Letters. 2008 582(6): 881-885.
  • Lin PC, Chen YL, Chiu SC, Yu YL, Chen SP, Chien MH, Chen KY, Lin SZ, Chiou TW, and Harn HJ*. Orphan nuclear receptor, Nurr-77 was a possible target gene of butylidenephthalide chemotherapy on glioblastoma multiform brain tumor. J Neurochem. 2008 106(3): 1017-1026.
  • Yiang GT…, Harn HJ…, Yu YL…, Hu SC, Hung YT, Hsieh CJ, Lin SZ and Wei CW*. Immunotherapy: rAAV2 expressing interleukin-15 inhibits HeLa cell tumor growth in mice. J Biomed Sci. 2009 16:47.
  • Xia W, Wei Y, Du Y, Liu J, Chang B, Yu YL, Huo LF, Miller S, and Hung MC*. Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Mol Carcinog. 2009 48 (7): 610-617.
  • Wei CW…, Lin CC…, Yu YL…, Lin CY, Lin PC, Wu MT, Chen CJ, Chang W, Lin SZ, Chen YL, and Harn HJ*. n-Butylidenephthalide induced apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2alpha and telomerase activity.  Acta Pharmacol Sin. 2009 30(9):1297-306.
  • Yu YL…, Wei CW…, Chen YL, Chen MHC, and Yiang GT*. Immunotherapy of breast cancer by single delivery with rAAV2-mediated interleukin-15 expression.Int J Oncol.2010 36(2): 365-370.
  • Yu YL…, Yu SL…, Su KJ, Wei CW, Jian MH, Lin PC, Tseng IH, Lin CC, Su CC, Chan DC, Lin SZ, Harn HJ, and Chen YL*. Extended MGMT promoter hypermethylation following n-Butylidenephthalide combined with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on inhibition of HCC carcinoma cells growth. J Agric Food Chem. 2010 58, 1630-1638.
  • Huo L, Wang YN, Xia W, Hsu SC, Lai CC, Li LY, Chang WC, Wang Y, Hsu MC, Yu YL, Huang TH, Ding Q, Chen CH, Tsai CH, and Hung MC*. RNA helicase A is a DNA-binding partner for EGFR mediated transcriptional activation in the nucleus. Proc Natl Acad Sci U S A. 2010 107(37), 16125-16130.
  • Chang TH, Tsai MF, Su KY, Wu SG, Huang CP, Yu SL, Yu YL, Lan CC, Yang CH, Lin SB, Wu CP, Shih JY, Yang PC*. Slug Confers Resistance to the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. Am J Respir Crit Care Med. 15;183(8):1071-1079, 2011.
  • Yu SL…, Lin SB…, Yu YL…, Chien MH, Su KJ, Lin CJ, Way TD, Yiang GT, Lin CC, Chan DC, Harn HJ, Chen YL*. Isochaihulactone protects PC12 cell against H(2)O(2) induced oxidative stress and exerts the potent anti-aging effects in D-galactose aging mouse model. Acta Pharmacol Sin. 2010 31(12):1532-1540.
  • Tseng HH…, Yu YL…, Chen YL, Chen JH, Chou CL, Kuo TY, Wang JJ, Lee MC, Huang TH, Chen MH, Yiang GT*. RC-RNase-induced cell death in estrogen receptor positive breast tumors through down-regulation of Bcl-2 and estrogen receptor. Oncol Rep.2011 (3):849-853.
  • Yu YL*…, Chou RH…, Chen LT, Shyu WC, Hsieh SC, Wu CS, Zeng HJ, Yeh SP, Yang DM, Hung SC, Hung MC*. EZH2 Regulates Neuronal Differentiation of Mesenchymal Stem Cells through PIP5K1C-dependent Calcium Signaling. J Biol Chem. 2011 286(11):9657-9667.
  • Yu YL*…, Su KJ…, Chen CJ, Wei CW, Lin CJ, Yiang GT, Lin SZ, Harn HJ, Chen YL*. Synergistic anti-tumor activity of isochaihulactone and paclitaxel on human lung cancer cells. J Cell Physiol. 2012 227:213-222.
  • Chou RH, Yu YL*, Hung MC*. The roles of EZH2 in cell lineage commitment. Am J Transl Res. 2011 3(3):243-250.
  • Yiang GT, Chou PL, Tsai HF, Chen LA, Chang WJ, Yu YL*, Wei CW*. Immunotherapy for SV40 T/t antigen-induced breast cancer by recombinant adeno-associated virus serotype 2 carrying interleukin-15 in mice. Int J Mol Med.2012 29: 809-814.
  • Lai TW, Lin SZ, Lee HT, Fan JR, Hsu YH, Wang HJ, Yu YL, Shyu WC*. HIF-1α binding to the Epac1 promoter recruits hematopoietic stem cells to the ischemic brain following stroke. J Mol Cell Biol. 2012 4(3):184-187.
  • Yiang GT…, Yu YL…, Chou PL, Tsai HF, Chen LA, Chen YH, Su KJ, Wang JJ, Bau DT, Wei CW*. The Cytotoxic Protein Can Induce Autophagocytosis in Addition to Apoptosis in MCF-7 Human Breast Cancer Cells. In Vivo. 2012 26(3):403-409.
  • Wu CS, Yen CJ, Chou RH, Li ST, Huang WC, Ren CT, Wu CY*, Yu YL*. Cancer-associated carbohydrate antigens as potential biomarkers for hepatocellular carcinoma. PLoS One. 2012 7(7):e39466. Epub Jul 13.
  • Yu YL*…, Chou RH…, Wu CH, Wang YN, Chang WJ, Tseng YJ, Chang WC, Lai CC, Lee HJ, Huo L, Chen CH, Hung MC*. Nuclear EGFR Suppresses Ribonuclease Activity of Polynucleotide Phosphorylase through DNAPK-mediated Phosphorylation at Serine 776. J Biol Chem. 2012 287(37):31015-31026.
  • Yang YC, Lin HY, Su KY, Chen CH, Yu YL, Lin CC, Yu SL, Yan HY, Su KJ, Chen YL*. Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model. Evid Based Complement Alternat Med. Epub 2012 Aug 16.
  • Chiou SH, Jiang BH……, Yu YL……, Chou SJ, Tsai PH, Chang WC, Chen LK, Chen LH, Chien Y, Chiou GY. Poly(ADP-ribose) polymerase 1 regulates nuclear reprogramming and promotes iPSC generation without c-Myc.  J Exp Med. 2013 Jan 14; 210(1):85-98. (……co-second author)
  • Yiang GT, Chen YH, Chou PL, Chang WJ, Wei CW*, Yu YL*. The NS3 protease and helicase domains of Japanese encephalitis virus trigger cell death via caspase‑dependent and ‑independent pathways. Mol Med Rep. 2013 Mar; 7(3):826-30.
  • Hsia TC, Tu CY, Chen YJ, Wei YL, Yu MC, Hsu SC, Tsai SL, Chen WS, Yeh MH, Yen CJ, Yu YL, Huang TC, Huang CY, Hung MC, Huang WC*. Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells. Mol Pharmacol. 2013 Apr; 83(4):857-69.
  • Yu YL*…, Chou RH…, Shyu WC…, Hsieh SC, Wu CS, Chiang SY, Chang WJ, Chen JN, Tseng YJ, Lin YH, Lee W, Yeh SP, Hsu JL, Yang CC, Hung SC, Hung MC*. Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke. EMBO Mol Med. 2013 Apr; 5(4):531-47.
  • Yu YL*, Chou RH, Liang JH, Chang WJ, Su KJ, Tseng YJ, Huang WC, Wang SC, Hung MC*. Targeting the EGFR/PCNA Signaling Suppresses Tumor Growth of Triple-Negative Breast Cancer Cells with Cell-Penetrating PCNA Peptides. PLoS One. 2013 Apr 8; 8(4):e61362.
  • Lin CH, Lee HT, Lee SD, Lee W, Cho CW, Lin SZ, Wang HJ, Okano H, Su CY,Yu YL, Hsu CY, Shyu WC*. Role of HIF-1α-activated Epac1 on HSC-mediated neuroplasticity in stroke model. Neurobiol Dis. 2013 Oct;58:76-91.
  • Chiang TY…, Yu YL…, Lin CW, Tsao SM, Yang SF, Yeh CB*. The circulating level of MMP-9 and its ratio to TIMP-1 as a predictor of severity in patients with community-acquired pneumonia. Clin Chim Acta. 2013 Sep 23, 424: 261-6.
  • Lee SD, Lai TW, Lin SZ, Lin CH, Hsu YH, Li CY, Wang HJ, Lee W, Su CY, Yu YL*, Shyu WC*. Role of stress-inducible protein-1 in recruitment of bone marrow derived cells into the ischemic brains. EMBO Mol Med.  2013 Aug; 5(8): 1227-46.
  • Chen YJ, Chien PH, Chen WS, Chien YF, Hsu YY, Wang LY, Chen JY, Lin CW, Huang TC, Yu YL, Huang WC* Hepatitis B Virus-Encoded X Protein Downregulates EGFR Expression via Inducing MicroRNA-7 in Hepatocellular Carcinoma Cells. Evid Based Complement Alternat Med.; 2013 Jun 11; 682380. doi: 10.1155/2013/682380. Epub.
  • Chou RH, Hsieh SC, Yu YL, Huang MH, Huang YC, Hsieh YH*. Fisetin Inhibits Migration and Invasion of Human Cervical Cancer Cells by Down-Regulating Urokinase Plasminogen Activator Expression through Suppressing the p38 MAPK-Dependent NF-κB Signaling Pathway. PLoS One. 2013 Aug 5;8(8):e71983. doi: 10.1371/journal.pone.0071983.
  • Yu YL…, Su KJ…, Hsieh YH, Lee HL, Chen TY, Hsiao PC, Yang SF*. Effects of EZH2 Polymorphisms on Susceptibility to and Pathological Development of Hepatocellular Carcinoma. PLoS One. 2013 Sep 10;8(9):e74870. doi: 10.1371/journal.pone.0074870.
  • Chang SL, Chou RH, Zeng HJ, Lin YH, Chiu TY, Yang DM, Hung SC, Lai CH, Hsieh JT, Shyu WC*, Yu YL*. Downregulation of DAB2IP Promotes Mesenchymal-To-Neuroepithelial Transition and Neuronal Differentiation of Human Mesenchymal Stem Cells. PLoS One. 2013 Sep 20;8(9):e75884. doi: 10.1371/journal.pone.0075884.
  • Wu CS, Yen CJ, Chou RH, Chen JN, Huang WC, Wu CY*, Yu YL*. Downregulation of microRNA-15b by hepatitis B virus X enhances hepatocellular carcinoma proliferation via fucosyltransferase 2-induced Globo H expression.Int J Cancer. 2014 Apr 1;134(7):1638-47.
  • Chen YJ, Yeh MH, Yu MC, Wei YL, Chen WS, Chen JY, Shih CY, Tu CY, Chen CH, Hsia TC, Chien PH, Liu SH, Yu YL, Huang WC*. Lapatinib--induced NF-kappaB activation sensitizes triple-negative breast cancer cells to proteasome inhibitors. Breast Cancer Res. 2013 Nov 12;15(6):R108.
  • Chiou GY…, Chien CS…, Wang ML…,  Chen MT…, Yang YP…, Yu YL…, Chien Y, Chang YC, Shen CC, Chio CC, Lu KH, Ma HI,  Chen KH,  Liu DM, Miller SA, Chen YW, Huang PI, Shih YH, Hung MC*, Chiou SH*. Epigenetic Regulation of the miR142-3p/Interleukin-6 Circuit in Glioblastoma. Mol Cell. 2013 Dec 12; 52(5): 679-692.
  • Ko CP…, Yu YL…, Hsiao PC, Yang SF, Yeh CB*. Plasma levels of soluble Axl correlate with severity of community-acquired pneumonia. Mol Med Rep. 2014 Apr 9(4):1400-4.
  • Yiang GT, Tsai HF, Chen JR, Chou PL, Wu TK, Liu HC, Chang WJ, Liu LC, Tseng HH*, Yu YL*. RC-6 ribonuclease induces caspase activation, cellular senescence and neuron-like morphology in NT2 embryonal carcinoma cells. Oncol Rep. 2014 Apr;31(4):1738-44.
  • Yiang GT, Chou RH, Chang WJ, Wei CW*, Yu YL*. Long-term expression of rAAV2-hIL15 enhances immunoglobulin production and lymphokine-activated killer cell-mediated human glioblastoma cell death. Mol Clin Oncol. 2013 Mar;1(2):321-325.
  • Yu YL…, Yiang GT…, Chou PL, Tseng HH, Wu TK, Hung YT, Lin PS, Lin SY, Liu HC, Chang WJ, Wei CW*. Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation. Mol Med Rep. 2014 Jun;9(6):2077-84.
  • Yu YL…, Su KJ…, Hsieh MJ, Wang SS, Wang PH, Weng WC, Yang SF*. Impact of EZH2 Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathologic Features. PLoS One. 2014 Apr 1;9(4):e93635. doi: 10.1371/journal.pone.0093635. eCollection.
  • Chang LC, Lin HY, Tsai MT, Chou RH, Lee FY, Teng CM, Hsieh MT, Hung HY, Huang LJ, Yu YL*, Kuo SC*. YC-1 inhibits proliferation of breast cancer cells by downregulating EZH2 expression via activation of c-Cbl and ERK. Br J Pharmacol. 2014 Sep;171(17):4010-25.
  • Chou RH, Lu CY; Wei-Lee, Fan JR, Yu YL*, Shyu WC*. The potential therapeutic applications of olfactory ensheathing cells in regenerative medicine. Cell Transplant. 2014;23(4-5):567-71.
  • Yeh CB…, Yu YL…, Lin CW, Chiou HL, Hsieh MJ, Yang SF*. Terminalia catappa attenuates urokinase-type plasminogen activator expression through Erk pathways in Hepatocellular carcinoma. BMC Complement Altern Med. 2014 Apr 30;14:141.
  • Wu CS, Lee TY, Chou RH, Yen CJ, Huang WC, Wu CY, Yu YL*. Development of a Highly Sensitive Glycan Microarray for Quantifying AFP-L3 for Early Prediction of Hepatitis B Virus-Related Hepatocellular Carcinoma. PLoS One. 2014 Jun 13;9(6):e99959.
  • Yiang GT, Chou PL, Hung YT, Chen JN, Chang WJ, Yu YL*, Wei CW*. Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells. Oncol Rep. 2014 Sep;32(3):1057-63.
  • Lai CH*, Chang CS, Liu HH, Tsai YS, Hsu FM, Yu YL, Lai CK, Gandee L, Pong RC, Hsu HW, Yu L, Saha D, Hsieh JT*. Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin. Oncotarget. 2014 Jul 30;5(14):5523-34.
  • Chou RH, Wang YN, Hsieh YH, Li LY, Xia W, Chang WC, Chang LC, Cheng CC, Lai CC, Hsu J L, Chang WJ, Chiang SY, Lee HJ, Liao HW, Chuang PH, Chen HY, Kuo SC, Chen CH, Yu YL* and Hung MC*. EGFR modulates DNA synthesis and repairs through Tyr phosphorylation of Histone H4. Dev Cell 2014 Jul 28;30(2):224-237. 
  • Chou RH, Chiu L, Yu YL*, Shyu WC*. The Potential Roles of EZH2 in Regenerative Medicine. Cell Transplant. 2015 Feb 2. [Epub ahead of print]
  • Chang LC…, Yu YL …, Liu CY, Cheng YY, Chou RH, Hsieh MT, Lin HY, Hung HY, Huang LJ, Wu YC, Kuo SC. The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1. Cancer Chemother Pharmacol. 2015 Jun;75(6):1303-15. doi: 10.1007/s00280-015-2765-0. Epub 2015 May
  • Chen JN, Yiang GT, Lin YF, Chou PL, Wu TK, Chang WJ, Chen C, Yu YL*. Rana catesbeiana ribonuclease induces cell apoptosis via the caspase-9/-3 signaling pathway in human glioblastoma DBTRG, GBM8901 and GBM8401 cell lines. Oncol Lett. 2015 Jun;9(6):2471-2476. Epub 2015 Apr 15.
  • Yiang GT, Chen JN, Wu TK, Wang HF, Hung YT, Chang WJ, Chen C, Wei CW, Yu YL*. Ascorbic acid inhibits TPA-induced HL‑60 cell differentiation by decreasing cellular H2O2 and ERK phosphorylation. Mol Med Rep. 2015 Oct;12(4):5501-7
  • Wu TK, Wei CW, Pan YR, Cherng SH, Chang WJ, Wang HF, Yu YL*. Vitamin C attenuates the toxic effect of aristolochic acid on renal tubular cells via decreasing oxidative stress‑mediated cell death pathways. Mol Med Rep. 2015 Aug 3. doi: 10.3892/mmr.2015.4167. [Epub ahead of print]
  • Yiang GT…, Yu YL …, Lin KT, Chen JN, Chang WJ, Wei CW. Acetaminophen induces JNK/p38 signaling and activates the caspase-9-3-dependent cell death pathway in human mesenchymal stem cells. Int J Mol Med.2015 Aug;36(2):485-92. doi: 10.3892/ijmm.2015.2254. Epub 2015 Jun 19.
  • Su KJ, Ho CC, Lin CW, Chen MK, Su SC, Yu YL*, Yang SF*. Combinations of FUT2 gene polymorphisms and environmental factors are associated with oral cancer risk. Tumour Biol. 2016 May;37(5):6647-52
  • Su KJ, Lin CW, Chen MK, Yang SF, Yu YL*, Effects of EZH2 promoter polymorphisms and methylation status on oral squamous cell carcinoma susceptibility and pathology. Am J Cancer Res. 2015 Oct 15;5(11):3475-84. eCollection 2015.
  • Chang LC, Yu YL*. Dietary components as epigenetic-regulating agents against cancer. Biomedicine (Taipei). 2016 Mar;6(1):2. doi: 10.7603/s40681-016-0002-8. Epub 2016 Feb 10.
  • Chang LC…, Yu YL …, Hsieh MT, Wang SH, Chou RH, Huang WC, Lin HY, Hung HY, Huang LJ, Kuo SC. A novel microtubule inhibitor, MT3-037, causes cancer cell apoptosis by inducing mitotic arrest and interfering with microtubule dynamics..Am J Cancer Res. 2016 Mar 15;6(4):747-63. eCollection 2016.
  • Yeh YW, Cheng CC, Yang ST, Tseng CF, Chang TY, Tsai SY, Fu E, Chiang CP, Liao LC, Tsai PW, Yu YL*, Su JL*.Targeting the VEGF-C/VEGFR3 axis suppresses Slug-mediated cancer metastasis and stemness via inhibition of KRAS/YAP1 signaling. Oncotarget. 2016 Nov 25. doi: 10.18632/oncotarget.13629. [Epub ahead of print]

Symposiums

  • Yu YL. The novel signaling of nuclear EGFR in cancer. 2007. Nov. The 1st international cancer symposium, Taichung, Taiwan.
  • Yu YL, et al. Investigation of the molecular mechanisms of neuron differentiation in human mesenchymal stem cells. 2008, May. 73rd Symposium: Control & Regulation of Stem Cells. New York, USA.
  • Yu YL, et al. Role of the polycomb group protein EZH2 in neuron differentiation of mesenchymal stem cells. 2009, April. 2nd Pan Pacific Symposium on Stem Cells Research. Taichung, Taiwan.
  • Yu YL, et al. Role of the polycomb group protein EZH2 in neuron differentiation of mesenchymal stem cells. 2009, June. Deregulation of Transcription in Cancer: Controlling Cell Fate Decisions. Kerry, Ireland.
  • Yu YL, et al. Targeting the nuclear EGFR signaling of human breast cancers via blockade of PCNA phosphorylation. 2011, Feb. 19th Symposium on Recent Advances in Cellular and Molecular Biology. Kaohsiung, Taiwan.
  • Yu YL, et al. EZH2 Regulates Neuronal Differentiation of Mesenchymal Stem Cells through PIP5K1C-dependent Calcium Signaling. 2011, April. 4th Pan Pacific Symposium on Stem Cells Research. Taichung, Taiwan.
  • Yu YL, et al. EZH2 Regulates Neuronal Differentiation of Mesenchymal Stem Cells through PIP5K1C-dependent Calcium Signaling. 2011, Global Academic Programs 2011 Conference. Houston, USA.
  • Yu YL, et al. Targeting the nuclear EGFR signaling of human breast cancers via blockade of PCNA phosphorylation. 2011, July. 36th FEBS Congress Biochemistry for Tomorrow's Medicine, Torino, Italy
  • Yu YL, et al. Linking Receptor Tyrosine Kinase and Chromation Regulation. 2011, Nov. Sister Institution Symposium of MDACC at CMU & H, Taichung, Taiwan.
  • Yu YL, et al. Epigenetic Regulation of Mesenchymal Stem Cells Differentiation by Polycomb Group Protein EZH2. 2011, Dec. The 10th Cross-Strait Symposium on Biomedical Research, Shanghai, China.
  • Yu YL, et al. Z-isochaihulactone causes G2/M cell cycle arrest and apoptosis by inducing DNA damage response in human TNBC cancer cells. 2012, Feb. 20th Symposium on Recent Advances in Cellular and Molecular Biology. Kaohsiung, Taiwan.
  • Yu YL, et al. Role of DAB2IP in modulating neuron differentiation of mesenchymal stem cells. 2012, April. 5th Pan Pacific Symposium on Stem Cells and Cancer Research. Taichung, Taiwan.
  • Yu YL, et al. Cancer Biology and Signaling Pathway. 2012, May. MD Anderson Cancer Center and iRICE (Taiwan) Joint Symposium, Houston, USA.
  • Yu YL, et al. Role of EZH2 in modulating neuron differentiation of mesenchymal stem cells. 2013, April. 6th Pan Pacific Symposium on Stem Cells and Cancer Research. Hsinchu, Taiwan.
  • Yu YL, et al. International symposium on biomedical sciences, Taichung, Taiwan. 2016, July.
  • Yu YL, et al. Frontiers in stem cell research and cell therapy & The 12th annual meeting of Taiwan society for stem cell research, Taichung, Taiwan. 2016, Oct.
  • Yu YL, et al. 2016 CMUH international cancer symposium, Taichung, Taiwan. 2016, Nov.